Taliglucerase alfa
Generic name: taliglucerase alfa [ TAL-i-GLOO-ser-ase-AL-fa ]
Brand name: Elelyso
Dosage form: intravenous powder for injection (200 units)
Drug class:Lysosomal enzymes
What is taliglucerase alfa?
Taliglucerase is used as an enzyme replacement in people with Type I Gaucher disease in adults and children at least 4 years old.
Gaucher disease is a genetic condition in which the body lacks the enzyme needed to break down certain fatty materials (lipids). Lipids can build up in the body, causing symptoms such as easy bruising or bleeding, weakness, anemia, bone or joint pain, enlarged liver or spleen, or weakened bones that are easily fractured.
Taliglucerase may improve the condition of the liver, spleen, bones, and blood cells in people with Type I Gaucher disease. However, taliglucerase is not a cure for this condition.
Taliglucerase may also be used for purposes not listed in this medication guide.
Warnings
Some people receiving a taliglucerase alfa injection have had a reaction when the medicine was injected, or up to 3 hours later. Tell your caregivers right away if you have a sudden headache, dizziness, warmth or tingling, chest pain, wheezing, nausea, or a red skin rash.
Before taking this medicine
Tell your doctor if you are pregnant. It is not known whether taliglucerase alfa will harm an unborn baby. However, having untreated or uncontrolled Type I Gaucher disease during pregnancy may cause new or worsening symptoms in the mother, or complications in the baby such as growth problems or bleeding. The benefit of treating your disease may outweigh any risks to the baby.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
How is taliglucerase alfa given?
Taliglucerase alfa is given as an infusion into a vein. A healthcare provider will give you this injection.
You may be given other medications to help prevent an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.
You may be given other medications to prevent certain side effects of taliglucerase alfa.
Taliglucerase alfa is usually given every other week. Follow your doctor's dosing instructions very carefully.
Your doctor may occasionally change your dose to make sure you get the best results.
Taliglucerase alfa doses are based on weight (especially in children and teenagers). Your dose needs may change if you gain or lose weight.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your taliglucerase alfa injection.
