Tavaborole

Class: Oxaboroles
Chemical Name: 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
Molecular Formula: C₇H₆BFO₂
CAS Number: 174671-46-6
Brands: Kerydin

Medically reviewed by Drugs.com on Feb 7, 2022. Written by ASHP.

Introduction

Antifungal; oxaborole (boron-containing compound).

Uses for Tavaborole

Onychomycosis

Topical treatment of onychomycosis of the toenails (tinea unguium, ringworm of the nail) caused by Trichophyton rubrum or T. mentagrophytes.

Tavaborole Dosage and Administration

Administration

Topical Administration

Apply 5% solution topically to affected toenails using dropper supplied by the manufacturer.

Do not administer orally or intravaginally; do not apply topically to eyes.

Clean and dry toenails prior to application.

Using dropper supplied by the manufacturer, place solution on each affected toenail; use dropper tip to spread solution over entire toenail surface and under toenail tip. More than a single drop of the solution may be necessary.

Avoid applying to skin that is not surrounding toenails being treated; wipe excess solution from surrounding skin.

Allow solution to dry on the toenails (this may take a couple of minutes).

Wash hands with soap and water after applying the drug.

Dosage

Adults

Onychomycosis

Topical

Apply 5% solution to affected toenails once daily for 48 weeks. Use amount sufficient to cover entire toenail surface and under toenail tip. (See Topical Administration under Dosage and Administration.)

Special Populations

No special population dosage recommendations.

Cautions for Tavaborole

Contraindications

• Manufacturer states none.

Warnings/Precautions

Sensitivity Reactions

May cause skin irritation; no evidence that the drug causes contact sensitization.

Administration Precautions

For topical use only. Do not use orally or intravaginally; do not apply to eyes.

Selection and Use of Antifungals

Prior to treatment of onychomycosis, confirm diagnosis by direct microscopic examination of scrapings from infected toenails mounted in potassium hydroxide (KOH) or by culture.

Specific Populations

Pregnancy

Category C.

Lactation

Not known whether distributed into human milk following topical application. Use with caution in nursing women.

Pediatric Use

Safety and efficacy not established in pediatric patients.

Geriatric Use

No o...