Tepadina

Generic name:thiotepa [ THYE-oh-TEP-a ]
Drug class:Alkylating agents

Medically reviewed by Drugs.com on Oct 1, 2020. Written by Cerner Multum.

What is Tepadina?

Tepadina is used to treat cancer of the breast, ovary, bladder, and certain body cavities.

Tepadina may also be used for purposes not listed in this medication guide.

Warnings

Tepadina can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, mouth sores, pale skin, tiredness, feeling short of breath).

Before taking this medicine

You should not be treated with Tepadina if you are allergic to it, or if you have recently received a vaccine.

Tell your doctor if you have ever had:

• a weak immune system; or

• liver disease.

Tell your doctor about all other cancer treatments you have recently received, including chemotherapy and radiation.

Using Tepadina may increase your risk of developing other cancers, such as leukemia. Ask your doctor about this risk.

Tell your doctor if you are planning a pregnancy. Both men and women must prevent pregnancy during treatment with Tepadina and for several months afterward.

Tepadina can harm an unborn baby if the mother or the father is using Tepadina.

• If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 1 year after your last dose.

• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Tepadina.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because Tepadina can harm an unborn baby.

You should not breastfeed while using Tepadina.

How is Tepadina given?

Tepadina is given as an infusion into a vein, or injected directly into the bladder or other body cavity. A healthcare provider will give you this injection.

When injected into the bladder, you will need to hold the medicine inside your bladder for 2 hours. Tell your caregivers if this causes you a great deal of discomfort. You may need to receive a smaller amount of the medicine to hold it comfortably in your bladder.

Tepadina is usually given once every 1 to 4 weeks. Follow your doctor's dosing ins...