Tepezza
Generic name:teprotumumab [ TEP-roe-TOOM-ue-mab ]
Drug class:Growth hormone receptor blockers
What is Tepezza?
Tepezza is an insulin-like growth factor-1 receptor inhibitor (IGF-1R).
Tepezza is used to treat thyroid eye disease (sometimes called Graves Eye Disease).
Thyroid eye disease is an autoimmune disorder in which the immune system attacks tissues around the eyes. Symptoms include dry or watery eyes, eye redness, bulging eyes, vision problems, and difficulty closing the eyes.
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
To make sure Tepezza is safe for you, tell your doctor if you have:
diabetes or hyperglycemia (high blood sugar);
Tepezza may harm an unborn baby. Use effective birth control to prevent pregnancy while you are receiving Tepezza and for at least 6 months after your last dose. Tell your doctor if you become pregnant.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
How is Tepezza given?
Tepezza is given as an infusion into a vein. A healthcare provider will give you this injection.
Tepezza is usually given once every 3 weeks for a total of 8 doses.
This medicine must be given slowly, and the infusion can take 60 to 90 minutes to complete.
Dosing information
Usual Adult Dose for Graves' Ophthalmopathy:
Initial dose: 10 mg/kg intravenously
Maintenance dose: 20 mg/kg intravenously every 3 weeks for 7 additional infusions
Use: Treatment of thyroid eye disease
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Tepezza.
What happens if I overdose?
Since Tepezza is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving Tepezza?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
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