Terramycin with Polymyxin B
Generic name:oxytetracycline hydrochloride and polymyxin B sulfate
Dosage form: Ophthalmic Ointment
Drug class:Ophthalmic anti-infectives
Medically reviewed by Drugs.com. Last updated on Mar 22, 2022.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Terramycin® and other antibacterial drugs, Terramycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
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Terramycin with Polymyxin B Description
Each gram of sterile ointment contains oxytetracycline HCl equivalent to 5 mg oxytetracycline, 10,000 units of polymyxin B sulfate, white petrolatum, and liquid petrolatum.
ACTIONS
Terramycin is a widely used antibiotic with clinically proved activity against gram-positive and gram-negative bacteria, rickettsiae, spirochetes, large viruses, and certain protozoa.
Polymyxin B Sulfate, one of a group of related antibiotics derived from Bacillus polymyxa, is rapidly bactericidal. This action is exclusively against gram-negative organisms. It is particularly effective against Pseudomonas aeruginosa (B. pyocyaneus), and Koch-Weeks bacillus, frequently found in local infections of the eye.
There is thus made available a particularly effective antimicrobial combination of the broad-spectrum antibiotic Terramycin as well as polymyxin B sulfate against primarily causative or secondarily infecting organisms.
INDICATIONS
The sterile preparation, Terramycin with Polymyxin B Sulfate Ophthalmic Ointment, is indicated for the treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by Terramycin with Polymyxin B Sulfate-susceptible organisms.
It may be administered topically alone, or as an adjunct to systemic therapy.
It is effective in infections caused by susceptible strains of staphylococci, streptococci, pneumococci, Hemophilus influenzae, Pseudomonas aeruginosa, Koch-Weeks bacillus, and Proteus.
To reduce the development of drug-resistant bacteria and maintain effectiveness of Terramycin and other antibacterial drugs, Terramycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric...