Tetrahydrozoline

Class: Vasoconstrictors
CAS Number: 522-48-5
Brands: Clear Eyes Triple Action Relief, Rohto Arctic, Rohto Ice, Rohto Relief, Visine Original

Medically reviewed by Drugs.com on Feb 10, 2022. Written by ASHP.

Introduction

Vasoconstrictor; an imidazoline-derivative sympathomimetic amine.

Uses for Tetrahydrozoline

Conjunctival Congestion

Temporary relief of conjunctival congestion, itching, and minor irritation.

Used alone or in fixed combination with astringents (i.e., zinc sulfate).

Controls hyperemia in patients with superficial corneal vascularity.

Ineffective in the treatment of delayed hypersensitivity reactions such as contact dermatoconjunctivitis.

Used for vasoconstrictor effect during some ocular diagnostic procedures; phenylephrine may be preferred.

Tetrahydrozoline Dosage and Administration

Administration

Ophthalmic Administration

Apply ophthalmic solution topically to the conjunctiva.

Remove contact lenses before administering ophthalmic solution; wait ≥15 minutes to reinsert contact lenses.

Do not administer discolored or cloudy solution.

Avoid contamination of the dropper tip.

Dosage

Available as tetrahydrozoline hydrochloride; dosage expressed in terms of the salt.

Pediatric Patients

Conjunctival Congestion

Ophthalmic

Children ≥6 years of age: 1–2 drops of a 0.05% ophthalmic solution in the affected eye(s) up to 4 times daily.

Adults

Conjunctival Congestion

Ophthalmic

1–2 drops of a 0.05% ophthalmic solution in the affected eye(s) up to 4 times daily.

Prescribing Limits

Pediatric Patients

Conjunctival Congestion

Ophthalmic

For self-medication: Maximum of 4 times daily; maximum duration of 3–4 days, unless directed by a clinician.

Adults

Conjunctival Congestion

Ophthalmic

For self-medication: Maximum of 4 times daily; maximum duration of 3–4 days, unless directed by a clinician.

Special Populations

No special population dosage recommendations at this time.

Cautions for Tetrahydrozoline

Contraindications

• Known hypersensitivity to tetrahydrozoline or any ingredient in the formulation.

Warnings/Precautions

Warnings

Glaucoma

Patients with narrow-angle glaucoma or other serious eye disease should consult a clinician before using ophthalmic solution.

General Precautions

Overuse

Possible irritation of conjunctiva and adverse systemic effects (par...