Class: beta-Adrenergic Blocking Agents
- Beta-Adrenergic Blocking Agents
- β-Adrenergic Blocking Agents
VA Class: OP101
CAS Number: 91524-16-2
Brands: Betimol, Istalol, Timoptic, Timoptic-XE
Introduction
Nonselective β-adrenergic blocking agent.
Uses for Timolol (EENT)
Ocular Hypertension and Glaucoma
Timolol: Reduction of elevated IOP in patients with open-angle glaucoma or ocular hypertension.
Current data suggest similar efficacy for timolol maleate and timolol as the hemihydrate. Efficacy of Istalol timolol maleate solution (formulated with potassium sorbate) administered as a 0.5% solution of timolol once daily also similar to that of timolol maleate (formulated without potassium sorbate) administered as a 0.5% solution of timolol twice daily.
Fixed-combination dorzolamide 2% and timolol 0.5%: Reduction of elevated IOP in patients with open-angle glaucoma or ocular hypertension who have not responded adequately (i.e., failed to achieve target IOP as determined after multiple measurements over time) to a topical β-adrenergic blocking agent. When administered twice daily, IOP-lowering effect was 1–3 mm Hg greater than that of dorzolamide 2% administered 3 times daily or timolol 0.5% administered twice daily and approximately 1 mm Hg less than that achieved with concurrent use of dorzolamide 2% administered 3 times daily and timolol 0.5% administered twice daily.
Fixed-combination brimonidine tartrate 0.2% and timolol 0.5%: Reduction of elevated IOP in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy because of inadequately controlled IOP. When administered twice daily, IOP-lowering effect was 1–3 mm Hg greater than that of brimonidine tartrate 0.2% administered 3 times daily, 1–2 mm Hg greater than that of timolol 0.5% administered twice daily, and approximately 1–2 mm Hg less than that achieved with concurrent use of brimonidine tartrate 0.2% administered 3 times dail.
