TNKase

Generic name:tenecteplase [ ten-EK-te-plase ]
Drug class:Thrombolytics

Medically reviewed by Drugs.com on Sep 13, 2021. Written by Cerner Multum.

What is TNKase?

TNKase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.

TNKase is used to prevent death in people who have had a heart attack (acute myocardial infarction).

TNKase may also be used for purposes not listed in this medication guide.

Warnings

If possible before you receive TNKase, tell your doctor if you have a brain tumor or aneurysm, high blood pressure, hemophilia or other bleeding disorder, a history of stroke, or if you have recently had a head injury or surgery on your brain or spinal cord.

In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received TNKase.

Before taking this medicine

You should not be treated with TNKase if you are allergic to it, or if you have:

• active bleeding inside your body;

• a recent history of medical trauma or injury;

• severe or uncontrolled high blood pressure;

• a genetic disorder affecting the blood vessels in your brain;

• a brain tumor, blood vessel disorder, or aneurysm (dilated blood vessel);

• a bleeding or blood clotting disorder (such as hemophilia);

• a history of stroke; or

• if you have had brain or spinal cord injury or surgery within the past 2 months.

If possible before you receive TNKase, tell your doctor if you have ever had:

• a stroke;

• bleeding in your brain, stomach, intestines, or urinary tract;

• high blood pressure;

• heart problems;

• an infection of the lining of your heart (also called bacterial endocarditis);

• liver or kidney disease;

• eye problems caused by diabetes;

• severe bruising or infection around a vein where an IV was placed;

• a serious injury or major surgery;

• an organ biopsy; or

• if you are pregnant or have recently had a baby.

In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.

How is TNKase given?

TNKase is given as an infusion into a vein. A healthcare provider will give you this injection.

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