Tolcapone
Generic name: tolcapone [ TOLE-ka-pone ]
Brand name: Tasmar
Dosage form: oral tablet (100 mg)
Drug class:Dopaminergic antiparkinsonism agents
What is tolcapone?
Tolcapone is used together with other medicines (carbidopa and levodopa) to treat symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. Tolcapone increases levels of levodopa in the body.
Tolcapone is usually given to people who are already taking carbidopa and levodopa but have not had successful treatment of symptoms.
Tolcapone may also be used for purposes not listed in this medication guide.
Warnings
You should not use tolcapone if you have liver disease, if you have ever had liver problems caused by tolcapone, or if you have ever had muscle damage or fever and confusion caused by using any medication.
Do not use tolcapone if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Tolcapone can cause liver failure. Call your doctor at once if you have unusual tiredness, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Your liver function will need to be checked often.
Before taking this medicine
You should not use tolcapone if you are allergic to it, or if you have:
liver disease;
a history of liver problems caused by tolcapone; or
a history of muscle damage or fever and confusion caused by using any medication.
Do not use tolcapone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Tolcapone can cause liver failure. You may be required to read and sign a Patient Consent form before you get a prescription for tolcapone.
To make sure tolcapone is safe for you, tell your doctor if you have ever had:
liver disease;
kidney disease; or
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