Trabectedin (Intravenous)

Medically reviewed by Drugs.com. Last updated on Mar 31, 2022.

Commonly used brand name(s)

In the U.S.

• Yondelis

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antineoplastic Agent

Uses for trabectedin

Trabectedin injection is used to treat certain types of cancer, including liposarcoma or leiomyosarcoma that cannot be treated with surgery or has spread to other parts of the body. It is used in patients who have received treatment with other medicines.

Trabectedin is to be given only by or under the supervision of your doctor.

Before using trabectedin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For trabectedin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to trabectedin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of trabectedin injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of trabectedin injection have not been performed in the geriatric population, no geriatric-specific problems have been documented to date.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving trabectedin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using trabectedin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Yellow Fever Vaccine

Using trabectedin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abametapir
• Adenovirus Vaccine
• Bacillus of Calmette and Guerin Vaccine, Live
• Boceprevir
• Carbamazepine
• Cholera Vaccine, Live
• Clarithromycin
• Cobicistat
• Conivaptan
• Dengue Tetravalent Vaccine, Live
• Fedratinib
• Fosnetupitant
• Fosphenytoin
• Idelalisib
• Indinavir
• Influenza Virus Vaccine, Live
• Itraconazole
• Ketoconazole
• Lopinavir
• Measles Virus ...