Trametinib
Generic name: trametinib [ tra-ME-ti-nib ]
Brand name: Mekinist
Dosage form: oral tablet (0.5 mg; 2 mg)
Drug class:Multikinase inhibitors
What is trametinib?
Trametinib is used alone or in combination with another medicine called dabrafenib (Tafinlar) to treat certain types of cancer in people who have a "BRAF" gene mutation. These medicines are for use in treating:
melanoma (skin cancer) that cannot be treated with surgery or has spread to other parts of the body (metastatic), or to prevent melanoma from coming back after surgery;
metastatic non-small cell lung cancer; or
advanced or metastatic anaplastic thyroid cancer for which there are no other treatment options.
Trametinib may also be used for purposes not listed in this medication guide.
Warnings
Using trametinib with dabrafenib may increase your risk of developing new skin cancer. Ask your doctor about the risk. Tell your doctor if you notice new skin symptoms such as redness, warts, sores that will not heal, or a mole that has changed in size or color.
Before taking this medicine
Tell your doctor if you have ever had:
heart disease, high blood pressure;
diabetes;
lung disease;
liver or kidney disease;
a stomach or intestinal disorder;
eye problems (especially a problem with your retina); or
bleeding problems, or a blood clot.
Using trametinib with dabrafenib may increase your risk of developing new skin cancer. Ask your doctor about the risk. Tell your doctor if you notice new skin symptoms such as redness, warts, sores that will not heal, or a mole that has changed in size or color.
Trametinib can harm an unborn baby if the mother or the father is using trametinib.
If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 4 months after your last dose.
It may be harder for you get pregnant while using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
If you are a man, use condoms if your sex partner is pregnant or is able to get pregnant, even if you've had a vasectomy. Keep using condoms for at least 4 months after your last dose.
Tell your doctor right away if a pregnancy occurs.
Do not breastfeed while using this medicine,
