Tretin X Gel
Generic name:tretinoin
Dosage form: gel
Drug class:Topical acne agents
Medically reviewed by Drugs.com. Last updated on Aug 23, 2021.
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The Tretin-X brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Description
TRETIN•X Gel, and Cream are used for the topical treatment of acne vulgaris. Each gram of TRETIN•X gel contains tretinoin in either of two strengths, 0.025% (0.25 mg) or 0.01% (0.1 mg) in a gel vehicle of hydroxypropyl cellulose, butylated hydroxytoluene, and alcohol (denatured with tert-butyl alcohol and brucine sulfate) 90% w/w. Each gram of TRETIN•X cream contains tretinoin in either of four strengths, 0.1% (1 mg), 0.05% (0.5 mg),0.0375% (0.375 mg), or 0.025% (0.25 mg) in a hydrophilic cream vehicle of stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water. Chemically, tretinoin is all-trans-retinoic acid. It has a molecular weight of 300.44 and has the following structural formula:
Clinical Pharmacology
Although the exact mode of action of TRETIN•X is unknown, current evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones.
Indications and Usage
TRETIN•X gel and cream are indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established.
Contraindications
Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.
