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Tretinoin Capsules
  • Professionals
  • FDA PI

Tretinoin Capsules

Dosage form: capsule
Drug class:Miscellaneous antineoplastics

Medically reviewed by Drugs.com. Last updated on Feb 1, 2022.

Rx only

WARNINGS

1. Experienced Physician and Institution
Patients with acute promyelocytic leukemia (APL) are at high risk in general and can have severe adverse reactions to tretinoin. Tretinoin should therefore be administered only to patients with APL under the strict supervision of a physician who is experienced in the management of patients with acute leukemia and in a facility with laboratory and supportive services sufficient to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity, including respiratory compromise. Use of tretinoin requires that the physician concludes that the possible benefit to the patient outweighs the following known adverse effects of the therapy.

2. Retinoic Acid-APL Syndrome
About 25% of patients with APL treated with tretinoin have experienced a syndrome called the retinoic acid-APL (RA-APL) syndrome characterized by fever.

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