Triamcinolone (Systemic)

Class: Adrenals
VA Class: RE101
CAS Number: 124-94-7
Brands: Aristocort, Aristospan, Azmacort, Kenalog

Medically reviewed by Drugs.com on Dec 27, 2021. Written by ASHP.

Introduction

Synthetic glucocorticoid; virtually no mineralocorticoid activity.

Uses for Triamcinolone (Systemic)

Treatment of a wide variety of diseases and conditions principally for glucocorticoid effects as an anti-inflammatory and immunosuppressant agent and for its effects on blood and lymphatic systems in the palliative treatment of various diseases.

Usually inadequate alone for adrenocortical insufficiency because essentially devoid of mineralocorticoid activity.

Adrenocortical Insufficiency

Corticosteroids are administered in physiologic dosages to replace deficient endogenous hormones in patients with adrenocortical insufficiency.

Because production of both mineralocorticoids and glucocorticoids is deficient in adrenocortical insufficiency, hydrocortisone or cortisone (in conjunction with liberal salt intake) usually is the corticosteroid of choice for replacement therapy.

If triamcinolone is used, must also administer a mineralocorticoid (fludrocortisone), particularly in infants.

Adrenogenital Syndrome

Lifelong glucocorticoid treatment of congenital adrenogenital syndrome.

In salt-losing forms, cortisone or hydrocortisone is preferred in conjunction with liberal salt intake; a mineralocorticoid may be necessary in conjunction through at least 5–7 years of age. A glucocorticoid, usually alone, is continued for long-term therapy after early childhood.

In hypertensive forms, a “short-acting” glucocorticoid with minimal mineralocorticoid activity (e.g., methylprednisolone, prednisone) is preferred; avoid long-acting glucocorticoids because of tendency toward overdosage and growth retardation.

Hypercalcemia

Treatment of hypercalcemia associated with malignancy.

Usually ameliorates hypercalcemia associated with bone involvement in multiple myeloma.

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