Trobicin

Generic name: spectinomycin
Dosage form: injectable suspension
Drug class:Miscellaneous antibiotics

Medically reviewed by Drugs.com. Last updated on Feb 21, 2022.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Trobicin Sterile Powder and other antibacterial drugs, Trobicin Sterile Powder should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

For intramuscular Injection

Trobicin Description

Trobicin Sterile Powder contains spectinomycin hydrochloride which is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. Sterile spectinomycin hydrochloride is the pentahydrated dihydrochloride salt of spectinomycin. The structural formula is represented below:

Spectinomycin hydrochloride is isolated as a white to pale buff crystalline dihydrochloride pentahydrate powder, molecular weight 495, and is stable in the dry state for 36 months.

Trobicin - Clinical Pharmacology

Trobicin Sterile Powder is rapidly absorbed after intramuscular injection. A single, two-gram injection produces peak serum concentrations averaging about 100 mcg/mL at one hour; a single, four-gram injection produces peak serum concentrations averaging 160 mcg/mL at two hours. Average serum concentrations of 15 mcg/mL for the two-gram dose and 31 mcg/mL for the four-gram dose were present eight hours after dosing.

Microbiology

Spectinomycin hydrochloride is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit.

In vitro studies have shown spectinomycin hydrochloride to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL).

Definitive in vitro studies have shown no cross-resistance of N. gonorrhoeae between spectinomycin hydrochloride and penicillin. The antibiotic is not significantly bound to plasma protein.

Indications and Usage for Trobicin

Trobicin Sterile Powder is indicated in the treatment of acute gonorrheal urethritis and proctitis in the male an...