Trudhesa

Generic name:dihydroergotamine mesylate
Dosage form: nasal spray
Drug class:Antimigraine agents

Medically reviewed by Judith Stewart, BPharm. Last updated on Sep 4, 2021.

What is Trudhesa?

Trudhesa is a prescription medicine used for the acute treatment of migraine with or without aura in adults.

• Trudhesa is not used to prevent migraine.
• Trudhesa is not used to treat other types of headaches such as hemiplegic (that make you unable to move on one side of your body) or basilar (rare form of migraine with aura) migraines.

It is not known if this medicine is safe and effective in children.

Important information

Trudhesa can cause serious side effects, including:

• Serious problems with blood circulation to your legs and feet (peripheral ischemia). Trudhesa can cause peripheral ischemia when you take it with certain medicines known as CYP3A4 inhibitors. Peripheral ischemia may lead to a stroke and death. Stop treatment and get emergency medical help right away if you have any of the following symptoms:
  • cramping and pain in your legs or hips
  • feeling of heaviness or tightness in your leg muscles
  • burning or aching pain in your feet or toes while resting
  • numbness, tingling, or weakness in your legs
  • cold feeling or color changes in 1 or both legs or feet
  • slurred speech
  • sudden weakness

Do not take medicines known as strong CYP3A4 inhibitors, such as:

• • ritonavir
  • erythromycin
  • ketoconazole
  • nelfinavir
  • clarithromycin
  • itraconazole

These are not all of the medicines that could affect how Trudhesa works. Your healthcare provider can tell you if it is safe to take Trudhesa with other medicines.

Who should not take Trudhesa?

You should not not take Trudhesa if you:

• are ..