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Uptravi
  • Treatments
  • Pulmonary Hypertension

Uptravi

Generic name:selexipag (oral/injection) [ se-LEX-i-pag ]
Drug class:Agents for pulmonary hypertension

Medically reviewed by Judith Stewart, BPharm. Last updated on Nov 3, 2021.

What is Uptravi?

Uptravi lowers blood pressure in your lungs by dilating (widening) blood vessels that supply blood to the lungs.

Uptravi is used to treat pulmonary arterial hypertension (PAH).

Uptravi helps keep your condition from getting worse and helps lower your risk of needing to be hospitalized for PAH.

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used with Uptravi.

Before taking this medicine

You should not use Uptravi if you are allergic to selexipag.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with selexipag. Your doctor may change your treatment plan if you also use:

To make sure Uptravi is safe for you, tell your doctor if you have ever had:

  • a condition called pulmonary veno-occlusive disease (narrowing of the veins that carry blood from the lungs to the heart); or

  • liver disease.

It is not known if selexipag will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using Uptravi.

How should I take Uptravi?

Take Uptravi exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Uptravi tablets are taken by mouth. You may take the tablets with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

Uptravi injection is given in a vein by a healthcare provider if you are unable to take medicine by mouth.

You should not stop taking Uptravi without your doctor's advice. Stopping suddenly may make your condition worse.

Store tablets at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Pulmonary Hypertension:

Initial dose: 200 mcg orally twice a day
Maintenance dose: Increase in increments of 200 mcg orally twice a day at weekly intervals to the highest tolerated dose
Maximum dose: 1600 mcg orally twice a day

Comment:
-If the patient reaches a dose that is not well tolerated, reduce to a previously tolerated dose.

Use: For the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce the risk of hospitalization for PAH