Generic name: urea
Dosage form: lotion
Drug class:Topical emollients
Medically reviewed by Drugs.com. Last updated on Nov 1, 2021.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. Read further information about unapproved drugs.
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Rx Only
For external use only. Not for ophthalmic use.
Description
Urea 40% is a keratolytic emollient which is a gentle, yet potent, tissue softener for nails and/or skin. Each gram of Urea 40% contains 40% urea as an active ingredient, and the following inactive ingredients: Purified Water, Propylene Glycol, Glyceryl Monostearate, Mineral Oil, Cetyl Alcohol, Phosphomer X-Polymer, Trolamine 99% , White Petrolatum, Xanthan Gum.
Urea is a diamide of carbonic acid with the following chemical structure:
Clinical Pharmacology
Urea gently dissolves the intracellular matrix which results in loosening of the horny layer of the skin and shedding of scaly skin at regular intervals, thereby softening hyperkeratotic areas of the skin.
Pharmacokinetics
The mechanism of action of topically applied urea is not yet known.
Indications and Usage
For debridement and promotion of normal healing of hyper...
