UTA Capsules

Generic name: methenamine, methylene blue, hyoscyamine sulfate and sodium phosphate, monobasic
Dosage form: capsule
Drug class:Urinary antispasmodics

Medically reviewed by Drugs.com. Last updated on Mar 22, 2022.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

DESCRIPTION:

UTA Capsules for oral administration.
Each capsule contains:
Methenamine.....120 mg
Sodium Phosphate Monobasic.....40.8 mg
Methylene Blue.....10 mg
Hyoscyamine Sulfate.....0.12 mg

METHENAMINE (hexamethylenetetramine) exists as colorless, lustrous crystals or white crystalline powder. Its solutions are alkaline to litmus. Freely soluble in water, soluble in alcohol and in chloroform.

SODIUM PHOSPHATE MONOBASIC exists as a white powder. It is freely soluble in water and practically insoluble in alcohol.

METHYLENE BLUE (methylthionine chloride) exists as dark green crystals. It is soluble in water and in chloroform; sparingly soluble in alcohol.

HYOSCYAMINE SULFATE is an alkaloid of belladonna. Exists as a white crystalline powder. Its solutions are alkaline to litmus. Affected by light. It is slightly soluble in water; freely soluble in alcohol; sparingly soluble in ether.

UTA Capsules contains inactive ingredients: Microcrystalline Cellulose, Magnesium Stearate, Mannitol and Croscarmellose.

CLINICAL PHARMACOLOGY:

METHENAMINE degrades in an acidic urine environment releasing formaldehyde which provides bactericidal or bacteriostatic action. It is well absorbed from the gastrointestinal tract. 70%-90% reaches the urine unchanged at which point it is hydrolyzed if the urine is acidic. Within 24 hours it is almost completely (90%) excreted; of this at pH5, approximately 20% is formaldehyde. Protein binding - some formaldehyde is bound to substances in the urine and surrounding tissues. Methenamine is freely distributed to body tissue and fluids but is not clinically significant as it does not hydrolyze at pH greater than 6.8.

SODIUM PHOSPHATE MONOBASIC an acidifier, helps to maintain an acid pH in the urine necessary for the degradation of methenamine.

METHYLENE BLUE possesses weak an