UTAC tablets
Generic name: methenamine mandelate and sodium phosphate, monobasic, monohydrate
Dosage form: tablet, film coated
Drug class:Urinary anti-infectives
Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.
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UTAC tablets Description
| Each Tablet Contains: | |
| Methenamine Mandelate | 500 mg |
| Sodium Phosphate Monobasic, Monohydrate | 500 mg |
Inactive Ingredients: D&C Yellow No.10 Lake, Hypromellose, Magnesium Silicate, Magnesium Stearate, Microcrystalline Cellulose, Mineral Oil, Polyvinylpyrrolidone, Silica, Sodium Starch Glycolate, Starch, Stearic Acid, Titanium Dioxide and Triacetin.
UTAC tablets - Clinical Pharmacology
Methenamine mandelate is rapidly absorbed and excreted in the urine. Formaldehyde is released by acid hydrolysis from methenamine with bactericidal levels rapidly reached at pH 5.0- 5.5. Proportionally less formaldehyde is released as urinary pH approaches 6.0 and insufficient quantities are released above this level for therapeutic response. In acid urine, mandelic acid exerts its antibacterial action and also contributes to the acidification of the urine. Mandelic acid is excreted by both glomerular filtration and tubular excretion. In acid urine, there is equally effective antibacterial activity against both gram-positive and gram-negative organisms, since the antibacterial action of mandelic acid and formaldehyde is nonspecific. With Proteus vulgaris and urea splitting strains of Pseudomonas and Aerobacter, results may be discouraging and particular attention is required in monitoring urinary pH and overall management.
