Vestronidase alfa
Generic name: vestronidase alfa [ ves-TRON-i-dase-AL-fa ]
Brand name: Mepsevii
Dosage form: intravenous solution (2 mg/mL)
Drug class:Lysosomal enzymes
What is vestronidase alfa?
Vestronidase alfa contains an enzyme that occurs naturally in the body in healthy people. Some people lack this enzyme because of a genetic disorder. Vestronidase alfa helps replace this missing enzyme in such people.
Vestronidase alfa is used to treat some of the symptoms of a genetic condition called mucopolysaccharidosis VII (MYOO-koe-pol-ee-SAK-a-rye-DOE-sis Seven) or MPS VII, also called Sly syndrome.
MPS VII is a metabolic disorder in which the body lacks the enzyme needed to break down certain natural substances. These substances can build up in the body, causing enlarged organs, abnormal bone structure, changes in facial features, breathing problems, heart problems, vision or hearing loss, and changes in mental or physical abilities.
Vestronidase alfa may improve walking ability in people with this condition. However, this medication is not a cure for MPS VII.
Vestronidase alfa may also be used for purposes not listed in this medication guide.
Warnings
An allergic reaction may occur during or shortly after infusion of vestronidase alfa. Tell your caregivers or get emergency medical help right away if you have any signs of a severe allergic reaction, such as sweating, trouble breathing, pale skin, blue lips or fingernails, and feeling like you might pass out.
Before taking this medicine
Tell your doctor if you have ever had:
a lung disease or breathing problems.
Tell your doctor if you are pregnant or breastfeeding.
How is vestronidase alfa given?
Vestronidase alfa is given as an infusion into a vein. A healthcare provider will give you this injection.
vestronidase alfa is usually given once every 2 weeks. Vestronidase alfa must be given slowly, and the infusion can take about 4 hours to complete.
About 30 to 60 minutes before each injection, you will be given other medications to help prevent a serious allergic reaction.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when vestronidase alfa is injected.
You will be watched closely for at least 60 minutes after receiving vestronidase alfa, to make sure you do not have an allergic reaction.
Vestronidase alfa doses are based on weight. Your dose needs may change if you gain or lose weight.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your vestronidase alfa injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
