Vetrimec Pour-On
Generic name: ivermectin pour-on solution
Dosage form: FOR ANIMAL USE ONLY
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(ivermectin topical solution)
for Cattle
Contains 5 mg ivermectin/mL
Parasiticide
Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.
INTRODUCTION
Vetrimec Pour-On (ivermectin topical solution) delivers internal and external parasite control in one convenient low-volume application. Vetrimec Pour-On (ivermectin topical solution) contains ivermectin, a unique chemical entity.
MODE OF ACTION
Ivermectin is a member of the macrocylic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.
This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand -gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocylic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
INDICATIONS
Vetrimec Pour-On (ivermectin topical solution) applied at the recommended dose level of 500 mcg/kg is indicated for the effective control of these parasites.
| Gastrointestinal Roundworms | |
| Ostertagia ostertagi (including inhibited stage) | (adults and L4) |
| Haemonchus placei | (adults and L4) |
| Trichostrongylus axei | (adults and L4) |
| T. colubriformis | (adults and L4) |
| Cooperia oncophora | (adults and L4) |
| Cooperia punctata | (adults and L4) |
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MEDICAL DEPARTMENTS
Cardiology
Pediatrics
Diabetes Care
Pre-natal Care
Ultrasound Echocardiogram
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