Vorapaxar

Generic name: vorapaxar [ VOR-a-PAX-ar ]
Brand name: Zontivity
Dosage form: oral tablet (2.08 mg)
Drug class:Protease-activated receptor-1 antagonists

Medically reviewed by Drugs.com on Dec 6, 2021. Written by Cerner Multum.

What is vorapaxar?

Vorapaxar is used to lower the risk of stroke or serious heart problems in people who have had a heart attack or a blood vessel disorder affecting circulation in the arms and legs.

Vorapaxar is sometimes used together with aspirin or clopidogrel (Plavix).

Vorapaxar may also be used for purposes not listed in this medication guide.

Warnings

You should not use vorapaxar if you have active bleeding, stomach or intestinal bleeding, a head injury, or if you have a history of stroke (including "mini-stroke"), bleeding in your brain, or increased pressure inside the skull.

Vorapaxar increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bloody or tarry stools, red or brown urine, any bleeding that will not stop, or if you cough up blood or vomit that looks like coffee grounds.

Before taking this medicine

You should not use vorapaxar if you are allergic to it, or if you have:

• active bleeding;

• stomach or intestinal bleeding;

• a head injury or bleeding in your head;

• a history of stroke;

• a history of transient ischemic attack (TIA) or "mini-stroke"; or

• a history of bleeding in your brain or increased pressure inside the skull.

Vorapaxar increases your risk of bleeding, which can be severe or life-threatening, especially if:

• you have a bleeding or blood clotting disorder such as hemophilia;

• you are an older adult;

• you are underweight;

• you have liver or kidney disease;

• you take a blood thinner (warfarin, Coumadin, Jantoven);

• you take certain antidepressants (Celexa, Paxil, Prozac, Zoloft, Cymbalta, Effexor, and others); or

• you take an NSAID (nonsteroidal anti-inflammatory drug) such as aspirin,