Generic name:denosumab [ den-OH-sue-mab ]
Drug class:Miscellaneous bone resorption inhibitors
Medically reviewed by Drugs.com. Last updated on Jan 13, 2022.
What is Xgeva?
Xgeva is a monoclonal antibody. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.
The Xgeva brand of denosumab is used to prevent bone fractures and other skeletal conditions in people with multiple myeloma, and in people with tumors that have spread to the bone.
Xgeva is also used to treat giant cell bone tumor in adults and teenagers with fully matured bone structure.
Xgeva is also used to treat high blood levels of calcium caused by cancer, when other medicines such as pamidronate or zoledronic acid (Zometa) have been used without success.
Prolia is another brand of denosumab used to treat osteoporosis in postmenopausal women who have high risk of bone fracture.
Warnings
This medication guide provides information about the Xgeva brand of denosumab. Prolia is another brand of denosumab used to treat osteoporosis in postmenopausal women who have high risk of bone fracture.
Do not use denosumab if you are pregnant.
You should not receive Xgeva if you are allergic to denosumab, or if you have low levels of calcium in your blood (hypocalcemia).
Before you receive this medicine, tell your doctor if you have kidney disease or if you are on dialysis.
Some people using Xgeva have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw...
