Xpovio
Generic name:selinexor [ SEL-i-NEX-or ]
Drug class:Miscellaneous antineoplastics
What is Xpovio?
Xpovio is used together with bortezomib and/or dexamethasone to treat multiple myeloma in adults. It is used:
- in combination with the medicines bortezomib and dexamethasone to treat adults with multiple myeloma who have received at least one prior treatment for their disease.
- in combination with dexamethasone to treat adults with multiple myeloma (MM) that has come back (relapsed) or that did not respond to previous treatment (refractory), and
- who have received at least 4 prior therapies, and
- whose disease did not respond to (refractory) to at least 2 proteasome inhibitor medicines, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody medicine.
Xpovio is also used in adults to treat certain types of diffuse large B-cell lymphoma that has come back (relapsed) or that did not respond to previous treatment (refractory) and who have received at least 2 prior therapies.
Xpovio was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.
Warnings
Xpovio affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, flu symptoms, cough, mouth ulcers, or trouble breathing,
Xpovio can also cause low platelet counts in your blood. Tell your doctor right away if you have unusual bruising or bleeding.
Before taking this medicine
To make sure Xpovio is safe for you, tell your doctor if you have:
cataracts;
bleeding problems; or
an active or recent infection.
You may need to have a negative pregnancy test before starting this treatment.
Both men and women using this medicine should use effective birth control to prevent pregnancy. Selinexor can harm an unborn baby if the mother or father is using this medicine.
Keep using birth control for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Xpovio.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because selinexor can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
Xpovio is not approved for use by anyone younger than 18 years old.
How should I take Xpovio?
Take Xpovio exactly as prescribed by your doctor. Your doctor will perform tests to make sure this medicine is the right trea..
