Zenapax
Generic name:daclizumab
Dosage form: injection, solution, concentrate
Drug class:Interleukin inhibitors
Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.
On This Page
Only physicians experienced in immunosuppressive therapy and management of organ transplant patients should prescribe Zenapax® (daclizumab). The physician responsible for Zenapax administration should have complete information requisite for the follow-up of the patient. Zenapax should only be administered by healthcare personnel trained in the administration of the drug who have available adequate laboratory and supportive medical resources.
Zenapax Description
Zenapax® (daclizumab) is an immunosuppressive, humanized IgG1 monoclonal antibody produced by recombinant DNA technology that binds specifically to the alpha subunit (p55 alpha, CD25, or Tac subunit) of the human high-affinity interleukin-2 (IL-2) receptor that is expressed on the surface of activated lymphocytes.
Daclizumab is a composite of human (90%) and murine (10%) antibody sequences. The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. The murine sequences were derived from the complementarity-determining regions of a murine anti-Tac antibody. The molecular weight predicted from the DNA sequence is 144 kilodaltons.
Zenapax 25 mg/5 mL is supplied as a clear, sterile, colorless concentrate for further dilution and intravenous administration. Each milliliter of Zenapax contains 5 mg of daclizumab and 3.6 mg sodium phosphate monobasic monohydrate, 11 mg sodium phosphate dibasic heptahydrate, 4.6 mg sodium chloride, 0.2 mg polysorbate 80, and may contain hydrochloric acid or sodium hydroxide to adjust the pH to 6.9. No preservatives are added.
Zenapax - Clinical Pharmacology
General
Mechanism of ActionDaclizumab functions as an IL-2 receptor antagonist that binds with high-affinity to the Tac subunit of the high-affinity IL-2 receptor complex and inhibits IL-2 binding. Daclizumab binding is highly specific for Tac, which is expressed on activ...
