Zirabev (Intravenous)

Generic name:bevacizumab-bvzr (intravenous route) [ be-va-SIZ-yoo-mab-- bvzr ]
Drug class:VEGF/VEGFR inhibitors

Medically reviewed by Drugs.com. Last updated on May 30, 2022.

Commonly used brand name(s)

In the U.S.

• Zirabev

Available Dosage Forms:

• Solution

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Bevacizumab

Uses for Zirabev

Bevacizumab-bvzr injection is used together with other cancer medicines to treat patients with metastatic (cancer that has spread) carcinoma of the colon or rectum.

Bevacizumab-bvzr injection is also used to treat nonsquamous, non-small cell lung cancer (NSCLC) that has spread, come back, or cannot be removed by surgery. It is also used to treat a type of brain tumor called glioblastoma that keeps coming back (recurrent).

Bevacizumab-bvzr injection is also used together with other medicines (eg, interferon alfa) to treat patients with metastatic kidney cancer. It is also used in combination with other medicines (eg, paclitaxel and cisplatin, or paclitaxel and topotecan) to treat patients with cervical cancer that is continuing, keeps coming back, or has spread to other parts of the body.

Bevacizumab-bvzr injection is also used in combination with other medicines (eg, paclitaxel, pegylated liposomal doxorubicin, topotecan, carboplatin and paclitaxel, or carboplatin and gemcitabine followed by Zirabev™ alone) to treat patients with platinum-resistant, platinum-sensitive, recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer with or without having previous surgery or who have received 2 previous treatments.

Bevacizumab is an antineoplastic that helps the body fight cancer. It prevents the growth of certain types of blood vessels to cancer cells. This helps to decrease the growth of cancer cells by starving the cells of nutrients that are needed to grow.

This medicine is to be given only by or under the immediate supervision of your doctor.

Before using Zirabev

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of bevacizumab-bvzr injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of bevacizumab-bvzr injection in the elderly. However, elderly patients are more likely to have age-related heart or blood vessel problems, which may require caution in patients receiving bevacizumab-bvzr injection.

Breastfeeding

There are no adequate studies i...