Zofran ODT

Generic name:ondansetron (oral) [ on-DAN-se-tron ]
Brand names: Zofran, Zofran ODT, Zuplenz
Drug class:5HT3 receptor antagonists

Medically reviewed by Drugs.com on Oct 11, 2021. Written by Cerner Multum.

What is Zofran ODT?

Zofran ODT blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Zofran ODT is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

Zofran ODT may be used for purposes not listed in this medication guide.

Warnings

You should not use Zofran ODT if you are also using apomorphine (Apokyn).

Before taking this medicine

You should not use Zofran ODT if:

• you are also using apomorphine (Apokyn); or

• you are allergic to Zofran ODT or similar medicines (dolasetron, granisetron, palonosetron).

To make sure Zofran ODT is safe for you, tell your doctor if you have:

• liver disease;

• an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

• congestive heart failure, slow heartbeats;

• a personal or family history of