Zokinvy

Generic name:lonafarnib [ LOE-na-FAR-nib ]
Drug class:Miscellaneous metabolic agents

Medically reviewed by Judith Stewart, BPharm. Last updated on Feb 9, 2021.

What is Zokinvy?

Zokinvy a prescription medicine used in people with certain rare genetic conditions that cause premature and rapid aging. Lonafarnib is for use in adults and children at least 12 months old whose bodies have reached a certain size (a body surface area of 0.39 square meters).

Zokinvy is used to lower the risk of death in people with Hutchinson-Gilford Progeria Syndrome (HGPS).

Zokinvy is also used to treat certain types of Progeroid Laminopathies that are "processing-deficient."

This medicine is not for use in people with non-HGPS Progeroid Syndromes or with Progeroid Laminopathies that are "processing-proficient."

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Lonafarnib can harm your unborn baby. Females who are able to become pregnant should use effective birth control during treatment with Zokinvy.

It is not known if Zokinvy is safe and effective in children under 12 months of age.

Before taking this medicine

You should not use Zokinvy if you are also using certain other medicines.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with Zokinvy. Your doctor may change your treatment plan if you also use:

• midazolam;

• St. John's wort;

• phenobarbital or other barbiturate medicine;

• an antibiotic or antifungal medicine;

• antiviral medicine to treat HIV or hepatitis C;

• cancer medicine...