Zontivity
Generic name:vorapaxar [ VOR-a-PAX-ar ]
Drug class:Protease-activated receptor-1 antagonists
What is Zontivity?
Zontivity helps to prevent platelets in your blood from sticking together and forming a blood clot. An unwanted blood clot can occur with certain heart or blood vessel conditions.
Zontivity is used to lower the risk of stroke or serious heart problems in people who have had a heart attack or a blood vessel disorder affecting circulation in the arms and legs.
Zontivity is sometimes used together with aspirin or clopidogrel (Plavix).
Warnings
You should not use Zontivity if you have active bleeding, stomach or intestinal bleeding, a head injury, or if you have a history of stroke (including "mini-stroke"), bleeding in your brain, or increased pressure inside the skull.
Zontivity increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bloody or tarry stools, red or brown urine, any bleeding that will not stop, or if you cough up blood or vomit that looks like coffee grounds.
Before taking this medicine
You should not use Zontivity if you are allergic to vorapaxar, or if you have:
active bleeding;
stomach or intestinal bleeding;
a head injury or bleeding in your head;
a history of stroke;
a history of transient ischemic attack (TIA) or "mini-stroke"; or
a history of bleeding in your brain or increased pressure inside the skull.
Vorapaxar increases your risk of bleeding, which can be severe or life-threatening, especially if:
you have a bleeding or blood clotting disorder such as hemophilia;
you are an older adult;
you are underweight;
you have liver or kidney disease;
you take certain antidepressants (Celexa, Paxil, Prozac, Zoloft, Cymbalta, Effexor, and others); or
you take an NSAID (nonsteroidal anti-inflammatory drug) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
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