Generic name:bupivacaine and meloxicam (injection route) [ bue-PIV-a-kane, mel-OX-i-kam ]
Drug class:Analgesic combinations
Medically reviewed by Drugs.com. Last updated on Apr 18, 2022.
Risk of Serious Cardiovascular and Gastrointestinal EventsCardiovascular Thrombotic EventsNonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use.Bupivacaine/meloxicam is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.Gastrointestinal Bleeding, Ulceration, and PerforationNSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events .
Commonly used brand name(s)
In the U.S.
- Zynrelef
Available Dosage Forms:
- Solution, Extended Release
Therapeutic Class: Anesthetic Combination
Pharmacologic Class: NSAID
Chemical Class: Amino Amide
Uses for Zynrelef
Bupivacaine and meloxicam combination injection is used to numb an area of your body and relieves pain for up to 72 hours after surgery, including surgery to treat a foot, ankle, knee, or abdominal or stomach problem. Bupivacaine is a local anesthetic. It causes a loss of feeling and prevents pain by blocking signals at the nerve endings. It does not cause loss of consciousness. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID).
This medicine is to be given only by or under the direct supervision of your doctor.
Before using Zynrelef
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make..
