Zyprexa IntraMuscular
Generic name:olanzapine (intramuscular route) [ oh-LAN-za-peen ]
Drug class:Atypical antipsychotics
Medically reviewed by Drugs.com. Last updated on Jan 8, 2022.
Risk of death is increased in elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Olanzapine is not approved for the treatment of patients with dementia-related psychosis .
Intramuscular route(Powder for Suspension, Extended Release)Patients are at risk for severe sedation (including coma) or delirium after each injection and must be observed for at least 3 hours in a registered facility with ready access to emergency response services. Because of this risk, olanzapine pamoate is available only through a restricted distribution program called olanzapine pamoate Patient Care Program and requires prescriber, healthcare facility, patient, and pharmacy enrollment. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Olanzapine pamoate is not approved for the treatment of patients with dementia-related psychosis .
Commonly used brand name(s)
In the U.S.
- ZyPREXA IntraMuscular
- ZyPREXA Relprevv
Available Dosage Forms:
- Powder for Solution
- Powder for Suspension, Extended Release
Therapeutic Class: Antipsychotic
Chemical Class: Thienobenzodiazepine
Uses for Zyprexa IntraMuscular
Olanzapine injection is used to treat agitation that occurs with schizophrenia and bipolar mania. This medicine should not be used to treat behavioral problems in older adult patients who have dementia or Alzheimer's disease.
Zyprexa® IntraMuscular injection is to be given only by or under the direct supervision of a doctor.
Zyprexa® Relprevv™ is available only under a special restricted distribution program called Zyprexa® Relprevv™ patient care program.
Before using Zyprexa IntraMuscular
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of olanzapine injection in the pediatric population. Safety and efficacy have not been established.
