Belinostat

Generic name: belinostat [ be-LIN-oh-stat ]
Brand name: Beleodaq
Dosage form: intravenous powder for injection (500 mg)
Drug class:Histone deacetylase inhibitors

Medically reviewed by Drugs.com on Dec 2, 2020. Written by Cerner Multum.

What is belinostat?

Belinostat is used to treat peripheral T-cell lymphoma after other cancer treatments did not work or have stopped working.

Belinostat was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to belinostat, but further studies are needed.

Belinostat may also be used for purposes not listed in this medication guide.

Warnings

Belinostat affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, flu-like symptoms, or unusual bleeding or bruising.

Before taking this medicine

Tell your doctor if you have ever had:

• an infection;

• high-dose or intensive chemotherapy;

• liver or kidney disease; or

• if you are sick with vomiting and diarrhea.

Belinostat can harm an unborn baby if the mother or the father is using belinostat.

• If you are a woman, do not use belinostat if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using belinostat.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

How is belinostat given?

Belinostat is given as an infusion into a vein. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take at least 30 minutes to complete.

Belinostat is given in a 21-day treatment cycle. You may need to use the medicine only during the first 5 days of each cycle. Your doctor will determine how long to treat you with this medicine.

You may be given medication to prevent nausea, vomiting, or diarrhea while you are receiving belinostat.

Belinostat affects your immune system. You may get infections more easily, even serious...