Besifloxacin

Class: Antibacterials
VA Class: OP210
Chemical Name: (+)-7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
Molecular Formula: C₁₉H₂₁ClFN₃O₃•HCl
CAS Number: 405165-61-9
Brands: Besivance

Medically reviewed by Drugs.com on May 12, 2022. Written by ASHP.

Introduction

Antibacterial; 8-chloro fluoroquinolone.

Uses for Besifloxacin

Bacterial Ophthalmic Infections

Topical treatment of conjunctivitis caused by Aerococcus viridans, CDC coryneform group G, Corynebacterium pseudodiphtheriticum, C. striatum, Haemophilus influenzae, Moraxella catarrhalis, M. lacunata, Pseudomonas aeruginosa, Staphylococcus aureus, S. epidermidis, S. hominis, S. lugdunensis, S. warneri, Streptococcus mitis group, S. oralis, S. pneumoniae, or S. salivarius.

Many cases of mild, acute bacterial conjunctivitis resolve spontaneously without anti-infective therapy. Although topical ophthalmic anti-infectives may shorten time to resolution and reduce severity and risk of complications, avoid indiscriminate use of topical anti-infectives.

Treatment of acute bacterial conjunctivitis generally is empiric; use of a broad-spectrum topical ophthalmic antibacterial usually recommended. In vitro staining and/or cultures of conjunctival material may be indicated in diagnosis and management of recurrent, severe, or chronic purulent conjunctivitis or when acute conjunctivitis does not respond to initial empiric topical treatment.

Besifloxacin Dosage and Administration

Administration

Ophthalmic Administration

Apply 0.6% ophthalmic suspension topically to the eye.

For topical ophthalmic use only; do not inject subconjunctivally and do not introduce directly into anterior chamber of the eye.

Wash hands prior to administration.

Invert the closed bottle containing besifloxacin ophthalmic suspension and shake once prior to each use.

Avoid contaminating applicator tip with material from eye, fingers, or other source.

Dosage

Available as besifloxacin hydrochloride; dosage expressed in terms of besifloxacin.

Pediatric Patients

Bacterial Ophthalmic Infections

Conjunctivitis

Children ≥1 year of age: Instill 1 drop of 0.6% suspension in the affected eye(s) 3 times daily (give doses 4–12 hours apart) for 7 days.

Adults

Bacterial Ophthalmic Infections

Conjunctivitis

Instill 1 drop of 0.6% suspension in the affected eye(s) 3 times daily (give doses 4–12 hours apart) for 7 days.