Binimetinib
Generic name: binimetinib [ BIN-i-ME-ti-nib ]
Brand name: Mektovi
Dosage form: oral tablet (15 mg)
Drug class:Multikinase inhibitors
What is binimetinib?
Binimetinib is used in combination with another medicine called encorafenib (Braftovi) to treat melanoma (skin cancer) in people who have a "BRAF" gene mutation. These medicines are for use in treating melanoma that cannot be treated with surgery or has spread to other parts of the body.
Binimetinib may also be used for purposes not listed in this medication guide.
Warnings
Binimetinib can cause birth defects. Do not use if you are pregnant. Avoid getting pregnant while using binimetinib and for at least 30 days after your last dose.
Before taking this medicine
You should not use binimetinib if you are allergic to it.
Tell your doctor if you have ever had:
heart disease, high blood pressure;
lung disease;
a muscle disorder;
liver or kidney disease;
eye problems (especially a problem with your retina); or
bleeding problems, or a blood clot.
Do not use binimetinib if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using binimetinib and for at least 30 days after your last dose.
Tell your doctor if you think you may be pregnant. You may need to have a negative pregnancy test before starting this treatment.
You should not breastfeed while using this medicine, and for at least 3 days after your last dose.
How should I take binimetinib?
Your doctor will perform blood tests to make sure you have the correct tumor type to be treated with binimetinib.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Binimetinib is usually taken twice per day (every 12 hours), with or without food.
Do not change your dose or dosing schedule without your doctor's advice.
If you vomit shortly after taking binimetinib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.
You will need frequent medical tests.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 6 hours. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attent...
