Blephamide

Generic name:sulfacetamide sodium and prednisolone acetate
Dosage form: ophthalmic ointment
Drug class:Ophthalmic steroids with anti-infectives

Medically reviewed by Drugs.com. Last updated on May 23, 2022.

Blephamide Description

Blephamide® (sulfacetamide sodium and prednisolone acetate ophthalmic ointment, USP) is a sterile topical ophthalmic ointment combining an antibacterial and a corticosteroid which have the following chemical structures:

Sulfacetamide sodium Prednisolone acetate

MW = 254.24 MW = 402.49

C8H9N2NaO3S•H2O C23H30O6

Chemical Names: Sulfacetamide sodium: N-sulfanilylacetamide monosodium salt monohydrate. Prednisolone acetate: 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate.

Each mL of Blephamide®contains: Actives: sulfacetamide sodium 10% and prednisolone acetate 0.2%;Inactives: phenylmercuric acetate 0.0008%;mineral oil; petrolatum and lanolin alcohol; and white petrolatum.

Blephamide - Clinical Pharmacology

Corticosteroids suppress the inflammatory response to a variety of agents and they probably delay or slow healing. Since corticosteroids may inhibit the body’s defense mechanism against infection, a concomitant antibacterial drug may be used when this inhibition is considered to be clinically significant in a particular case.

When a decision to administer both a corticosteroid and an antibacterial is made, the administration of such drugs in combination has the advantage of greater patient compliance and convenience, with the added assurance that the appropriate dosage of both drugs is administered, plus assured compatibility of ingredients when both types of drugs are in the same formulation and, particularly, that th...