Blephamide Ophthalmic Suspension

Generic name:sulfacetamide sodium and prednisolone acetate
Dosage form: ophthalmic suspension
Drug class:Ophthalmic steroids with anti-infectives

Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.

Blephamide Ophthalmic Suspension Description

BLEPHAMIDE®ophthalmic suspension is a sterile, topical anti-inflammatory/anti-infective combination product for ophthalmic use.

Structural Formulas

MW=254.24 C8H9N2NaO3S·H2O MW=402.49 C23H30O6

Chemical Names

Sulfacetamide sodium: N-sulfanilylacetamide monosodium salt monohydrate.
Prednisolone acetate: 11ß, 17, 21-trihydroxypregna-1, 4-diene-3, 20-dione 21-acetate.

Each mL of BLEPHAMIDE®ophthalmic suspension contains:

Actives: sulfacetamide sodium 10%, prednisolone acetate (microfine suspension) 0.2%.

Inactives: benzalkonium chloride (0.004%); edetate disodium; polysorbate 80; polyvinyl alcohol 1.4%; potassium phosphate, monobasic; purified water; sodium phosphate, dibasic; sodium thiosulfate; hydrochloric acid and/or sodium hydroxide to adjust pH (6.6 to 7.2).

Blephamide Ophthalmic Suspension - Clinical Pharmacology

Corticosteroids suppress the inflammatory response to a variety of agents and they probably delay or slow healing. Since corticosteroids may inhibit the body's defense mechanism against infection, a concomitant antibacterial drug may be used when this inhibition is considered to be clinically significant in a particular case.

When a decision to administer both a corticosteroid and an antibacterial is made, the administration of such drugs in combination has the advantage of greater patient compliance and convenience, with the added assurance that the appropriate dosage of both drugs is administered. When both types of drugs are in the same formulation, compatibility of ingredients is assured and the correct v..