Bosulif
Generic name:bosutinib [ boe-SUE-tin-ib ]
Drug class:BCR-ABL tyrosine kinase inhibitors
What is Bosulif?
Bosulif interferes with the growth of some cancer cells.
Bosulif is used in adults to treat a type of blood cancer called Philadelphia chromosome-positive chronic myelogenous leukemia (CML).
Bosulif is usually given after other treatments have failed.
Warnings
Do not use Bosulif if you are pregnant or breastfeeding a baby.
Take Bosulif with food.
Do not break or crush a Bosulif tablet. The medicine from a crushed or broken pill can be dangerous if it gets on your skin. Ask your doctor or pharmacist how to safely handle and dispose of a broken tablet.
Stop using Bosulif and call your doctor at once if you have fever, easy bruising or bleeding, shortness of breath, jaundice (yellowing of the skin or eyes), swelling or rapid weight gain, blood in your stools, or severe and ongoing vomiting, stomach pain, or diarrhea.
Before taking this medicine
You should not use Bosulif if you are allergic to bosutinib.
To make sure Bosulif is safe for you, tell your doctor if you have ever had:
heart disease;
liver disease; or
kidney disease.
You may need to have a negative pregnancy test before starting this treatment.
Bosutinib may harm an unborn baby. Use effective birth control while you are using this medicine, and for at least 2 weeks after your last dose. Tell your doctor right away if you become pregnant.
You should not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
How should I take Bosulif?
Bosulif is usually taken once per day. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Take with food.
Swallow the tablet whole and do not crush, chew, or break it. The medicine from a crushed or broken pill can be dangerous if it gets on your skin. If this happens, wash your skin with soap and water. Ask your pharmacist how to safely dispose of a broken pill.
Bosulif can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.
You should not stop using Bosulif without your doctor's advice.
Store at room temperature away from moisture and heat.
Dosing information
Usual Adult Dose for Chronic Myelogenous Leukemia:
Newly-diagnosed:
400 mg orally once daily
Duration of therapy: Until disease progression or patient intolerance
