Bosutinib
Generic name: bosutinib [ boe-SUE-tin-ib ]
Brand name: Bosulif
Dosage form: oral tablet (100 mg; 400 mg; 500 mg)
Drug class:BCR-ABL tyrosine kinase inhibitors
What is bosutinib?
Bosutinib is used in adults to treat a type of blood cancer called Philadelphia chromosome-positive chronic myelogenous leukemia (CML).
Bosutinib is usually given after other treatments have failed.
Bosutinib may also be used for purposes not listed in this medication guide.
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not use bosutinib if you are allergic to it.
Tell your doctor if you have ever had:
heart disease;
liver disease; or
kidney disease.
You may need to have a negative pregnancy test before starting this treatment.
Bosutinib may harm an unborn baby. Use effective birth control while you are using bosutinib, and for at least 2 weeks after your last dose. Tell your doctor right away if you become pregnant.
You should not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
How should I take bosutinib?
Bosutinib is usually taken once per day. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Take with food.
Swallow the tablet whole and do not crush, chew, or break it. The medicine from a crushed or broken pill can be dangerous if it gets on your skin. If this happens, wash your skin with soap and water. Ask your pharmacist how to safely dispose of a broken pill.
Bosutinib can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.
You should not stop using bosutinib without your doctor's advice.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking bosutinib?
Grapefruit may interact with bosutinib and lead to unwanted side effects. Avoid...
