Brompheniramine and Pseudoephedrine Drops

Generic name: maleate and pseudoephedrine hydrochloride
Dosage form: liquid
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

Brompheniramine and Pseudoephedrine Drops Description

Brompheniramine Maleate 1 mg and Pseudoephedrine HCl 7.5 mg Drops is an antihistaminic drop for oral administration containing the following amounts of active ingredients in each 1 mL dropperful:
Brompheniramine Maleate, USP …….....…………………. 1 mg
Pseudoephedrine HCl …….....…….....……………. 7.5 mg

Inactive Ingredients: Citric Acid, Cotton Candy Flavor, Glycerin, Propylene Glycol, Purified Water, Saccharin Sodium, Sodium Benzoate, Sorbitol, and Xanthan Gum.

Brompheniramine Maleate is an antihistamine having the chemical name 2-pyridinepropanamine, -[4-bromophenyl)-N,N-dimethyl-,(±)-,[Z]-2-butenedioate (1:1) with the following chemical structure:


Pseudoephedrine Hydrochloride is a nasal decongestant with the chemical name, Benzenemethanol,-[1-(methylamino)ethyl]-,[S-(R*,R*)],hydrochloride. Its structure is as follows:

Brompheniramine and Pseudoephedrine Drops - Clinical Pharmacology

Brompheniramine Maleate
Brompheniramine Maleate is a histamine antagonist, specifically an H1-receptor-blocking agent belonging to the alkylamine class of antihistamines. Antihistamines appear to compete with histamine for receptor sites on effector cells. Brompheniramine also has anticholinergic (drying) and sedative effects. Among the antihistaminic effects, it antagonizes the allergic response (vasodilatation, increased vascular permeability, increased mucus secretion) of nasal tissue. Brompheniramine is well absorbed from the gastrointestinal tract, with peak plasma concentration after a single, oral dose of 4 mg reached in 5 hours; urinary excretion is the major route of elimination, mostly as products of biodegradation; the liver is as