Butenafine

Class: Benzylamines
ATC Class: D01AE23
VA Class: DE102
Chemical Name: N- (4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine hydrochloride
Molecular Formula: C₂₃H₂₇N•ClH
CAS Number: 101827-46-7
Brands: Lotrimin Ultra, Mentax

Medically reviewed by Drugs.com on Jul 22, 2021. Written by ASHP.

Introduction

Antifungal; benzylamine.

Uses for Butenafine

Dermatophytoses

Treatment of tinea corporis (body ringworm) and tinea cruris (jock itch) caused by Epidermophyton floccosum, Trichophyton mentagrophytes, T. rubrum, or T. tonsurans.

Treatment of tinea pedis (athlete’s foot) caused by E. floccosum, T. mentagrophytes, T. rubrum, or T. tonsurans.

Available for self-medication (OTC use) for treatment of tinea corporis, tinea cruris, and tinea pedis.

Do not use for scalp or nail infections.

Has not been evaluated in immunocompromised patients.

Topical antifungals usually effective for treatment of uncomplicated tinea corporis or tinea cruris. An oral antifungal may be necessary when tinea corporis or tinea cruris is extensive, dermatophyte folliculitis is present, infection is chronic or does not respond to topical therapy, or patient is immunocompromised because of coexisting disease or concomitant therapy.

Topical antifungals usually effective for treatment of uncomplicated tinea pedis. An oral antifungal may be necessary for treatment of hyperkeratotic areas on palms and soles, for chronic moccasin-type tinea pedis, and for tinea unguium (fingernail or toenail dermatophyte infections, onychomycosis).

Pityriasis (Tinea) Versicolor

Treatment of pityriasis (tinea) versicolor caused by Malassezia furfur (Pityrosporum orbiculare or P. ovale).

Has not been evaluated in immunocompromised patients.

Topical antifungals generally effective; an oral antifungal (with or without a topical antifungal) may be necessary in patients who have extensive or severe infections or have failed to respond to or have frequent relapses with topical therapy.

Butenafine Dosage and Administration

Administration

Topical Administration

Apply topically to the skin as a 1% cream.

Avoid contact with eyes, nose, mouth, and other mucous membranes.

Clean affected areas with soap and water; dry thoroughly prior to applying cream. May be applied after bathing.

Massage cream gently into affected areas. Wash hands after application process.

Do not use occlusive dressings or wrappings.

When treating tinea pedis, pay special attention to spaces between toes. Also, wear well-fitting, ventilated shoes and change shoes and socks at least once daily.

Dosage

Pediatric Patients

Dermatophytoses

Tinea Corporis or Tinea Cruris

Children ≥12 years of age: Apply to affected area and immediately surrounding skin once daily for 2 weeks.

If clinical improvement does not occur after treatment, diagnosis and therapy should be reevaluated.