Canagliflozin and metformin
Generic name: canagliflozin and metformin [ KAN-a-gli-FLOE-zin-and-met-FOR-min ]
Brand names: Invokamet, Invokamet XR
Dosage forms: oral tablet (150 mg-1000 mg; 150 mg-500 mg; 50 mg-1000 mg; 50 mg-500 mg); oral tablet, extended release (150 mg-1000 mg; 150 mg-500 mg; 50 mg-1000 mg; 50 mg-500 mg)
Drug class:Antidiabetic combinations
What is canagliflozin and metformin?
Canagliflozin and metformin is a combination medicine used with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Canagliflozin and metformin is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease.
Canagliflozin and metformin is also used to reduce the risk of end-stage kidney disease and hospitalization or death from heart problems in adults who also have kidney problems caused by type 2 diabetes.
canagliflozin and metformin is not for treating type 1 diabetes.
Canagliflozin and metformin may also be used for purposes not listed in this medication guide.
Warnings
You should not use this medicine if you have severe kidney disease or diabetic ketoacidosis.
Canagliflozin can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.
Before taking this medicine
You should not use canagliflozin and metformin if you are allergic to canagliflozin or metformin, or if you have:
severe kidney disease; or
ketoacidosis (call your doctor for treatment).
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking canagliflozin and metformin.
Canagliflozin may increase your risk of lower leg amputation, especially if you have had a prior amputation, a foot ulcer, heart disease, circulation problems, or nerve damage.
Tell your doctor...
