Capastat
Generic name:capreomycin sulfate
Dosage form: injection, powder, for solution
Drug class:Streptomyces derivatives
Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.
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The use of Capastat® Sulfate (Capreomycin for Injection, USP) in patients with renal insufficiency or preexisting auditory impairment must be undertaken with great caution, and the risk of additional cranial nerve VIII impairment or renal injury should be weighed against the benefits to be derived from therapy.
Refer toANIMAL PHARMACOLOGYfor additional information.
Since other parenteral antituberculosis agents (streptomycin, viomycin) also have similar and sometimes irreversible toxic effects, particularly on cranial nerve VIII and renal function, simultaneous administration of these agents with Capastat Sulfate is not recommended. Use with nonantituberculosis drugs (polymyxin A sulfate, colistin sulfate, amikacin, gentamicin, tobramycin, vancomycin, kanamycin, and neomycin) having ototoxic or nephrotoxic potential should be undertaken only with great caution.
Usage in Pregnancy: The safety of the use of Capastat Sulfate in pregnancy has not been determined.
Pediatric Usage: Safety and effectiveness in pediatric patients have not been established.
Capastat Description
Capastat Sulfate is a polypeptide antibiotic isolated from Streptomyces capreolus. It is a complex of 4 microbiologically active components which have been characterized in part; however, complete structural determination of all the components has not been established.
Capreomycin is supplied as the disulfate salt and is soluble in water. In complete solution, it is almost colorless.
Each vial contains the equivalent of 1 g capreomycin activity.
The structural formula is as follows:
