Capitrol

Generic name:chloroxine
Dosage form: Shampoo
Drug class:Topical anti-infectives

Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.

Capitrol Description

Capitrol is an antibacterial shampoo containing 2% (w/w) chloroxine (each gram contains 20 mg chloroxine) suspended in a base of sodium octoxynol-2 ethane sulfonate, water, PEG-6 lauramide, dextrin, sodium lauryl sulfoacetate, sodium dioctyl sulfosuccinate, 1% benzyl alcohol, PEG-14M, magnesium aluminum silicate, fragrance, EDTA, and color. May contain citric acid to adjust pH.

Chloroxine is a synthetic antibacterial compound that is effective in the treatment of dandruff and seborrheic dermatitis when incorporated in a shampoo.

The chemical name of chloroxine is 5,7-dichloro-8-hydroxyquinoline. The chemical structure of chloroxine is:

Capitrol - Clinical Pharmacology

Well controlled studies demonstrate Capitrol effectively reduces the excess scaling in patients with dandruff or seborrheic dermatitis. Though the cause of dandruff is not known, it is thought to be the result of accelerated mitotic activity in the epidermis. The presumed mechanism of action to reduce scaling would be to slow down the mitotic activity.

The role of microbes in seborrheic dermatitis is not known; however, Staphylococcus aureus and Pityrosporon species are often present in increased numbers during the course of the disease. Chloroxine is antibacterial, inhibiting the growth of Gram-positive as well as some Gram-negative organisms. Antifungal activity against some dermatophytes and yeasts also has been shown.

The absorption, metabolism and pharmacokinetics of Capitrol in humans have not been studied.

Indications and Usage for Capitrol

Capitrol is indicated in the treatment of dandruff and mild to - moderately severe seborrheic dermatitis of the scalp. Clinical studies indicate that improvement may be observed after 14 days of therapy.

Contraindications

Capitrol is contraindicated in those patients with a history of hypersensitivity to any of the listed ingredients.

Warnings

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