Caplacizumab
Generic name: caplacizumab [ KAP-la-SIZ-ue-mab ]
Brand name: Cablivi
Dosage form: injectable kit (11 mg)
Drug class:Platelet aggregation inhibitors
What is caplacizumab?
Caplacizumab is used to treat acquired thrombotic thrombocytopenic purpura (aTTP) in adults. Caplacizumab is given together with immunosuppressant medication and plasma exchange (transfusion).
Caplacizumab may also be used for purposes not listed in this medication guide.
Warnings
Caplacizumab can increase your risk of bleeding. Call your doctor if you have unusual bruising or bleeding, or any bleeding that will not stop.
Before taking this medicine
You should not use caplacizumab if you are allergic to it.
Tell your doctor if you have ever had a bleeding or blood clotting disorder such as hemophilia.
Follow your doctor's instructions about using caplacizumab if you are pregnant. Caplacizumab may increase the risk of bleeding in both mother and baby. However, the benefit of treating aTTP in the mother during pregnancy may outweigh those risks. Tell your doctor right away if you become pregnant.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
How is caplacizumab given?
Caplacizumab is injected under the skin, or given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
Caplacizumab and plasma exchange are usually started on the same day. Caplacizumab is then continued for 30 days or longer after your last daily plasma exchange.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.
Caplacizumab must be mixed with a liquid (diluent) before using it. When using injections by yourself, be sure you understand how to properly mix and store the medicine.
Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.
If you need surgery, dental work, or a medical procedure, you may need to stop using caplacizumab for at least 7 days ahead. Tell any doctor or dentist who treats you that you currently use this medicine.
Store caplacizumab in its original carton in the refrigerator. Protect from light and do not freeze.
You may store an unopened caplacizumab carton at room temperature for up to 2 months. Keep track of when you took the carton out of the refrigerator, and do not return it to the refrigerator once the medicine has reached room temperature.
If you cannot use the mixed medicine right away, store it in the refrigerator and use it within 4 hours.
Each vial (bottle) is for one use only. Throw it away after one ...
