Carbamide Peroxide
Class: Anti-infectives, Miscellaneous
ATC Class: D02AE01
VA Class: OR900
CAS Number: 124-43-6
Brands: Auralyt, Auro, Clearcanal, Debrox, Gly-Oxide, Murine
Introduction
Source of hydrogen peroxide and nascent oxygen; release of oxygen results in mild mechanical effervescence.
Uses for Carbamide Peroxide
Cerumen Removal
Occasional aid to soften, loosen, and remove excessive cerumen (earwax) from external ear canal.
Oral Irritation and Inflammation
Oral debriding agent and oral wound cleanser for topical treatment of canker sores (aphthous ulcers) and minor wounds or gum inflammation resulting from minor dental procedures, dentures, orthodontic appliances, accidental injury, or other irritations of the mouth and gums.
Aid in removal of phlegm, mucus, or other secretions associated with occasional sore mouth.
Adjunct to oral hygiene when normal cleansing measures are inadequate or impossible (e.g., total-care geriatric patients) or adjunct to oral hygiene after regular brushing.
Carbamide Peroxide Dosage and Administration
Administration
Otic Administration
Instill into external ear canal as a 6.5% otic solution.
For topical otic use only.
Avoid contact with eyes. If contact with eyes occurs, flush eyes with water and consult clinician.
Remove hearing aids before administering the otic solution.
Tilt head sideways and instill 5–10 drops of otic solution into ear; do not insert applicator tip into ear canal.
Keep solution in ear canal for several minutes by maintaining tilted head or placing cotton or an ear plug in the ear.
Foaming may occur in ear canal and crackling sound may be heard when otic solution contacts earwax and oxygen is released.
Recap otic solution container after each use.
Any earwax remaining after treatment may be removed by gently flushing ear canal with warm water using soft rubber bulb ear syringe.
Oral, Topical Use Only
Apply 10% oral topical solution to mouth only; do not swallow the oral topical solution.
Avoid contact with eyes.
Do not dilute.
Apply oral topical solution directly from bottle onto affected mouth area(s); expectorate after 2–3 minutes.
Alternatively, use oral topical solution as a mouth rinse by placing 10–20 drops onto tongue, mixing the solution with saliva by swishing it around in mouth over affected area(s) for at least 1 minute, and expectorating.
Dosage
Pediatric Patients
Cerumen Removal
Otic
Children ≥12 years of age: Instill 5–10 drops of 6.5% otic solution into external ear canal twice daily for up to 4 days or as directed by clinician. (See Otic Administration under Dosage and Administration.)
Oral Irritation and Inflammation
Oral Topical
Children ≥2 years of age: For direct application, apply several drops of 10% oral topical solution to affected mouth area(s) up to 4 times daily, after meals and at bedtime, or as directed by clinician (dent...
