Carboprost Injection

Generic name: carboprost tromethamine
Dosage form: injection, solution
Drug class:Uterotonic agents

Medically reviewed by Drugs.com. Last updated on Jan 1, 2022.

Carboprost Injection Description

Carboprost tromethamine injection, USP, an oxytocic, contains the tromethamine salt of the (15S)-15 methyl analogue of naturally occurring prostaglandin F2α in a sterile solution suitable for intramuscular injection.

Carboprost tromethamine, is the established name for the active ingredient in carboprost tromethamine injection, USP. Four other chemical names are:

1. (15S)-15-methyl prostaglandin F2α tromethamine salt

2. (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-(3S)-3-hydroxy-3-methyl-1-octenyl]cyclopentyl]-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

3. Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9α,11α,13E,15S)-,compound with 2-amino-2-(hydroxy-methyl)-1,3-propanediol (1:1)

The structural formula is represented below:

The molecular formula is C21H36O5.C4H11NO3. The molecular weight of carboprost tromethamine, USP is 489.64. It is a white to off-white crystalline powder. It generally melts between 95° and 105° C, depending on the rate of heating.

Carboprost tromethamine, USP dissolves readily in water at room temperature at a concentration greater than 75 mg/mL.

Each mL of carboprost tromethamine injection, USP contains carboprost tromethamine, USP equivalent to 250 mcg of carboprost, 83 mcg tromethamine, 9 mg sodium chloride, and 9.45 mg benzyl alcohol added as preservative. When necessary, pH is adjusted with sodium hydroxide and/or hydrochloric acid. The solution is sterile.