Ceftolozane and tazobactam (Intravenous)

Medically reviewed by Drugs.com. Last updated on Mar 10, 2022.

Commonly used brand name(s)

In the U.S.

• Zerbaxa

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antibiotic Combination

Pharmacologic Class: Cephalosporin

Uses for ceftolozane and tazobactam

Ceftolozane and tazobactam combination injection is used alone or in combination with metronidazole to treat complicated bacterial infections in many different parts of the body (eg, stomach, kidneys). It is also used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).

Ceftolozane and tazobactam combination is an antibiotic that belongs to the group of medicines known as cephalosporins and beta-lactamase inhibitors. It works by killing bacteria and preventing their growth. However, ceftolozane and tazobactam will not work for colds, flu, or other virus infections.

Ceftolozane and tazobactam is to be given only by or under the direct supervision of your doctor.

Before using ceftolozane and tazobactam

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ceftolozane and tazobactam, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to ceftolozane and tazobactam or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ceftolozane and tazobactam combination injection to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP) in children. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ceftolozane and tazobactam combination injection to treat complicated bacterial infections in many different parts of the body (eg, stomach, kidneys) in newborns to children younger than 18 years of age. Safety and efficacy have been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ceftolozane and tazobactam combination injection in the elderly. However, elderly patients are more likely to have unwanted effects and age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving ceftolozane and tazobactam combination injection.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving ceftolozane and taz...