Centussin DHC

Generic name: dihydrocodeine bitartrate, brompheniramine maleate, and phenylephrine hydrochloride
Dosage form: liquid
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

Centussin DHC Liquid

NDC 23359-018-16
Rx Only

CV

DESCRIPTION:
Each 5 mL (one teaspoonful) for oral administration contains:
Dihydrocodeine Bitartrate*..... 3 mg
*(WARNING- May be habit forming)
Brompheniramine Maleate..... 4 mg
Phenylephrine Hydrochloride..... 7.5 mg

Centussin DHC Liquid also contains: Glycerin, Propylene Glycol, Sorbitol, Citric Acid, Sodium Citrate,
Sodium Saccharin, Grape Flavor, Purified Water.

Dihydrocodeine Bitartrate is an antitussive with the chemical name (Morphinan-6-ol,4,5-epoxy-3-methoxy-
17-methyl-, (5α, 6α)-2,3-dihydroxybutanedioate (1:1) (salt). It has the following structural formula:



Brompheniramine Maleate is an antihistamine having the chemical name, 2-Pyridinepropanamine,
γ-(4-bromophenyl)-N, N-dimethyl-, (±)-,(Z)-2-butenedioate (1:1). With the following structure:


Phenylephrine hydrochloride is an orally effective nasal decongestant. Chemically it is (-)-m-Hydroxy-α-
[(methylamino)methyl]benzyl alcohol hydrochloride. Its chemical structure is as follows:

Centussin DHC - Clinical Pharmacology

Dihydrocodeine is a semi-synthetic narcotic analgesic related to codeine, with multiple actions
qualitatively similar to th