Cerliponase alfa (Intracerebroventricular)

Medically reviewed by Drugs.com. Last updated on Mar 21, 2022.

Commonly used brand name(s)

In the U.S.

Brineura

Available Dosage Forms:

Solution

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Enzyme

Uses for cerliponase alfa

Cerliponase alfa injection is used to treat late infantile neuronal ceroid lipofuscinosis type 2 (CLN2) or tripeptidyl peptidase 1 (TPP1) deficiency. It helps slow down the loss of walking ability in children 3 years of age and older.

Cerliponase alfa is to be given only by or under the direct supervision of your doctor.

Before using cerliponase alfa

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For cerliponase alfa, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to cerliponase alfa or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of cerliponase alfa injection in children 3 years of age and older. However, safety and efficacy have not been established in children younger than 3 years of age.

Geriatric

No information is available on the relationship of age to the effects of cerliponase alfa injection in geriatric patients.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Cerliponase alfa Intracerebroventricular